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The Longevity Equation Journal

A physician-led exploration of the biological systems that shape aging, performance, and long-term resilience.

Grounded in clinical practice. Written by Anil Bajnath, MD, and the Institute for Human Optimization. New entries published periodically.

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Longevity equation journal

Alzheimer’s Disease, the Four Horsemen, and What the AMBAR Trial Actually Found

Anil Bajnath, MD

Published on: 14/09/2026

Explore Alzheimer's disease, the Four Horsemen framework, and what the AMBAR trial reveals about therapeutic plasma exchange (TPE) for brain health.

healthy aging exerciseLongevity Medicineaging research breakthroughs

Partial Cellular Reprogramming: The Breakthrough That Could Reverse Aging

Institute for Human Optimization Team

Published on: 09/03/2026

Scientists are exploring cellular reprogramming using Yamanaka factors to reset biological age, restore tissue function, and potentially reverse aging.

cellular reprogrammingage reversal researchepigenetic reprogrammingYamanaka factorslongevity sciencepartial cellular reprogrammingepigenetic aginginduced pluripotent stem cellsaging research breakthroughs